Black Seed Oil for Inflammatory Diseases

Black seed oil has potent anti-inflammatory effects, its benefit for a range of inflammatory diseases is well recognised

In many diseases both acute and chronic it is inflammation that causes damage to tissues. Nigella sativa seeds, black seed oil and oil extracts have demonstrated a range of anti inflammatory effects. The main action of black seed oil is due to the inhibitory effects on inflammatory mediators and cells.

In many diseases inflammation results in damage to the body.

One of the major pro-inflammatory signalling proteins in the body is called tumor necrosis factor alpha (TNF-alpha). Thymoquinone is an extract of Nigella sativa which has been shown to reduce production of  TNF-alpha in response to inflammatory stimuli.[i]

Certain cells within the body are specifically designed to induce inflammation though the production signalling molecules. Nigella sativa fixed oils and extract thymoquinone have been found to inhibit the production of eicosanoids and the process of lipid peroxidation both of which mediate inflammation. These pharmacological properties of the oil support the traditional use of N. sativa and its derived products as a treatment for rheumatism and related inflammatory diseases.[ii]

Inflammation can also occur in many solid cancers like pancreatic cancer. Thymoquinone has been shown to be a potent inhibitor of inflammation in pancreatic cancer cells again by reducing the action of TNFalpha[iii]

Osteoporosis is a disease of bone thinning which has been linked to oxidative stress and inflammation. The effect of N. sativa and its extract Thymoquinone on modulating the immune response by inhibiting inflammatory cytokines such as interleukin-1 and 6 and the transcription factor, nuclear factor κB have shown promise in its potential as anti-osteoporotic agent. [vi]

N. sativa and its extract Thymoquinone reduces oxidative stress and inflammation which contributes to bone thinning in osteoporosis

Anti-allergy actions of black seed oil and extracts

Allergies are another group of conditions in which inflammation is the main pathological mechanisms. In allergic reactions interleukins 5 and 13 (IL-5 and IL-13) play key roles in recruiting specific inflammatory cells.[iv] Thymoquinone, extract of N. sativa, has been shown to inhibit IL-5 and IL-13 mRNA expression and protein production.

Clinical anti-inflammatory effects of N. sativa oil have been demonstrated in a prospective and double blind trial of patients with allergic rhinitis. The results of the trial show that N. sativa reduces the presence of the nasal mucosal congestion, nasal itching, runny nose, sneezing attacks, turbinate hypertrophy, and mucosal pallor after two weeks of treatment. [v]


Nigella sativa black seed oil is clinically beneficial for patients with allergic rhinitis

[i] El Gazzar MA, El Mezayen R, Nicolls MR, Dreskin SC. Thymoquinone attenuates proinflammatory responses in lipopolysaccharide-activated mast cells by modulating NF-kappaB nuclear transactivation. Biochim Biophys Acta. 2007 Apr;1770(4):556-64.

[ii] Houghton PJ, et al. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med. 1995 Feb;61(1):33-6.

[iii] Chehl N, Chipitsyna G, Gong Q, Yeo CJ, Arafat HA. Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB (Oxford). 2009 Aug;11(5):373-81.

[iv] El Gazzar MA. Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation. Inflamm Res. 2007 Aug;56(8):345-51.

[v] Nikakhlagh S, Rahim F, Aryani FH, Syahpoush A, Brougerdnya MG, Saki N. Herbal treatment of allergic rhinitis: the Nigella sativa. Am J Otolaryngol 2011; 32(5): 402-407.

[vi] Shuid AN, Mohamed N, Mohamed IN, Othman F, Suhaimi F, Mohd Ramli ES, Muhammad N, Soelaiman IN. Nigella sativa: A Potential Antiosteoporotic Agent. Evid Based Complement Alternat Med. 2012; 2012():696230.

Black seed oil for inflammatory diseases
Article Name
Black seed oil for inflammatory diseases
In many diseases both acute and chronic it is inflammation that causes damage to tissues. Nigella sativa seeds, black seed oil and oil extracts have demonstrated a range of anti inflammatory effects.

39 thoughts on “Black seed oil for inflammatory diseases

  1. Janet says:

    you don’t say anything about dosage or how to apply this oil. if one were to take orally, how much is recommended?

    • nabiblackseed says:

      Hi, thanks for your question. It depends on a few factors, firstly, your weight and height (the bigger your are the more you need to achieve the necessary blood/tissue concentrations of anything). Secondly, the indication, if you let me know why you are taking it then I can elaborate for that particular condition. Generally the dosage for most things will be somewhere between 1 – 3 teaspoons daily. In more serious conditions higher doses may be needed.

      • lauralee novak says:

        about the dosing of the oil.. I have Complex regional Pain syndrome, Osteoporosis, gastro paresis.. among other immune disorders.. I weigh about 96lbs and want to order for daily consumption and use on my skin..I have used it topically to battle horribly dry skin from mal nutrition issues and it it helping..thank you for any insight

        • nabiblackseed says:

          Dear Laurelee, You have a number of complex health problems. I think you would need to start on three table spoons daily. After 1 month you could try to reduce down to two but if you felt you needed then increase back to three. You will notice once you regularly take Black seed oil the beneficial effects (increase energy, concentration etc) this helps you to titrate the dose you need.

  2. Dixie Langston says:

    I came across the link to your website through GreenMedInfo. I am fascinated with all I have read so far. I was wondering if taking Black Seed oil will help with joint pain. I usually take Glucosamine and Chondroitin Sulfate but would rather take something with better benefits.

    Thank you for any advice you can share.

    Dixie Langston

    • nabiblackseed says:

      Hi Dixie, Welcome! Joint pain is mainly due to inflammation cause by joint wear and tear, black seed oil has well recognised and powerful anti-inflammatory actions as well as being an analgesic (pain killer). I would advise you to continue with your current supplements additionally you could give black seed a one months trial and see its effects for yourself. Kind regards.

  3. Louise says:

    Hi, I have fibromyalgia and PCOS and was curious also how I would take this and the dose.
    I’m 5’3″ and 84kg.

    Many thanks

    • nabiblackseed says:

      Hi Louise, there are a lot of reviews on-line which indicate people who suffer from both fibromyalgia and poly cystic ovarian syndrome (PCOS) can get significant benefit from black seed oil. Black seed oil is highly beneficial for weight loss as it increases the metabolism and reduces appetite. A clinical study has proven very significant reduction of body weight, waist circumference, and systolic blood pressure in the group taking Nigella sativa. It is also a diuretic and regulates blood glucose and lipid levels. All these effects will be beneficial to you. You should start taking one teaspoon 3 times a day. Let us know how you get on after a month of this regime. Kind regards. Ash

  4. hazel Gooding says:

    My daughter is 7 years old and has problems with constipation, she also, we think has an overactive bladder, she has no control and needs to frequently urinate. A friend of mine recommended black sesame seeds and I wondered if you would advise this for a child?

    • nabiblackseed says:

      Hi Hazel, Its safe for children and works wonders for constipation. Whether it will work for an over-active bladder? I don’t know.

  5. Devi says:

    I have had lymes for about 7 years and although through diet, exercise and select antioxidants I am able to deal with most of the related issues, I still have a fair amount of joint pain. How much would you recommend for this? I am 5’4″ amd around 140, 63 yrs.

    • nabiblackseed says:

      Dear Devi
      Black seed oil has strong antimicrobial action against a wide range of bacteria, fungi and viruses. It also has action against parasites including Toxoplasma gondii. I have searched to see if it has been trialled against Borrelia burgdorferi (pathogen in lymes) and could not find anything.

      Black seed utilises your body’s own immune system to fight infections whilst keeping it in check to prevent the effects from backfiring and making you unwell. In the specific case of lymes disease just from a symptomatic point of view it should improve things as it is anti-inflammatory and analgesic. One teaspoon three times a day should be enough.

      Please do keep me updated if on how you get on, it will add to the knowledge base about black seed for Lymes (certainly if you search on-line support forums for lymes you will find some people have tried and do recommend it for this indication)

      Warm regards

  6. kiran says:

    I am 40 years old with early Rheumatoid Arthritis. No swelling, redness or stiffness yet. Mild pains in many joints. Lots of food sensitivities have developed. . Can’t take gluten, dairy, lentils, night shades, nuts or seeds. I am 5 feet 7 inches and weight is 108 lbs. Pls advise.

    • nabiblackseed says:

      Dear Kiran

      There are a number of way in which black seed oil can help you: –
      1) Potent analgesic and anti-inflammatory action for reducing symptoms of Rheumatoid Arthritis See here
      2) Immunomodulatory actions to reduce the underlying autoimmune mechanism of the disease See here
      3) Reno-protective and hepato-protective actions to protect your kidneys and liver against side effects from any conventional medicine you might be taking
      4) Reduction of food intolerance / allergy (this is in fact one of the aspects of Nigella sativa use that Nestle is trying to patent)

      Take one teaspoon of black seed oil three times daily.
      Kind regards Team

  7. Sue says:


    I’m recovering from adrenal fatigue and have a decreased thyroid function as a result, with slightly higher than normal blood pressure and some developing insulin resistance. I’m 51, 5ft 11″ tall and heavy (not actually sure how heavy, but certainly in the obese category although I don’t look it). I have a lot of trouble now with water retention and hormone regulation. I’ve gained weight fast.

    I’ve been using black seed oil for a while, but not really knowing how much to take, so I was just taking 1tsp a day when I remembered! How should I really dose this for maximum effect? Given my size and my various issues that I want to knock on the head once and for all.


    • nabiblackseed says:

      Dear Sue
      Based on your parameters you need to take more than 1 teaspoon daily. I would advise a trial of 3 teaspoons portions daily, one in the morning 30 mins before breakfast, one before teatime and one before bed. Follow each dose with a small amount of honey or fruit juice. Try this for two weeks and if needed you may need to increase the serving size to knock the problems on the head. Although it is good to eat after taking black seed oil maximum effect is derived from taking it before a meal and with a 30 min gap before eating.
      The problems you describe (borderline blood pressure, insulin resistance, hormonal stress and obesity) can all be helped significantly with black seed oil and this has been demonstrated in human trials, some ones which may interest you listed below. (Insulin resistance) (Metabolic syndrome) (Oxidative Stress and Hypertension) (Blood pressure effects)

      Nabi Blackseed Oil Team

  8. Sue says:

    Thank you very much for your reply. I will now try 3 tsps per day as instructed.

    The bottles are so small though. I just bought 2, but will have to get more on standby for these doses.

    Why is the honey or juice recommended? That will be a glucose hit. How does that help? If that is explained in the links please forgive me. I have a little more work to do this evening and then I can sit and read the links.

    I actually like the taste. I also take fermented cod liver oil, but that’s pretty horrible!


    • nabiblackseed says:

      Your welcome. The honey or juice is to facilitate the flow of all the oil into the stomach as being a thick liquid a proportion of it will line throat and oesophagus. Some people also find this helps with the taste. I do agree with you that the oil tastes good and this is a hallmark of slow cold pressed oil which is extracted without any chemicals. Be wary of harsher oils.

  9. barbara says:

    I have been roasting and blending “black seeds” in my morning smoothies. I am wondering if eating the black seeds is equivalent to taking the oil. I generally finely chopped the seeds ( black seed, chia, pumpkin and almonds) very well first.

    • nabiblackseed says:

      Dear Barbara
      Sounds great for keeping your health in order, for fighting some disease larger doses of the active ingredients are needed and oil is able to provide this as it contains many spoons of pressed seeds in one spoon of oil. It must be said the whole seed contains valuable components (Nigellone, which has powerful activities against allergies is found in the black skin of the seed) this is why unfiltered oil is the most valuable and concentrated in healing components.
      All the best
      Team @

  10. annie says:

    Hi. I’m 42 with multiple large uterine fibroids. Any hope of shrinking them even a little with black seed oil? I’m almost scared to go to the gynae because the first thing they will recommend is surgery. I want to try and shrink them myself. any help? Thank you.

    • nabiblackseed says:

      Dear Annie
      Well worth a try. Black seed oil regulates abnormal cell turnover and that is one of the underlying issues in fibroids. Ladies who have used it for this purpose report positive results.
      Kind regards
      Team @

  11. Nosheen says:

    Hi, I was recently diagnosed with under active throid gland and high levels of uric acid. As a result of this, i have gained almost a stone in weight over last year, skin got drier and my hair are falling so much. I am 38 years old. I have always been aware of the health benefits of black seeds and have ordered 3 bottles to start with. But how could it have a direct impact on the thyroid gland? Also, i am very reluctant to use the conventional medicines (synthetic thyroxin hormone) for this problem. Could you please recommend the dosage needed for this. Thank you.

    • nabiblackseed says:

      Dear Nosheen
      Although there have been no studies looking at the effects of black seed oil on hypothyroidism many of the symptoms you describe (dry skin, weight gain,hair loss) are improved with black seed oil use. Please post an update as to how you get on. Kind regards
      Team @

  12. Jennifer Bond says:

    My daughter is 22 yrs old and has fibromyalgia. Suffers daily with pain and has for about 10 yrs now. Where do I get Black Seed Oil, will it help her and what would the dosage be. She weighs between 70 and 80 kgs as it is too painful for her to exercise. Also our Rhodesian Ridgeback female (4yrs old) is suffering with arthritis in her hips. Will the oil help her and what dosage as well. She’s 31kgs

    • nabiblackseed says:

      Dear Ms. Bond
      Fibromyalgia is a poorly understood condition. It is postulated by some that he underlying cause is a viral or microbial infection and by others that it is an immune disorder. Black seed oil has been used by many with the condition who have found great benefit as it improves energy levels, reduces inflammation and has analgesic and anti-depressant properties. Symptomatically it should be of benefit. Three teaspoons daily before food or with a light meal should be more than enough.
      Black seed and black seed oil is used for animals including horses and dogs and is beneficial for their ailments too. Mix some in with each meal.
      You can buy the black seed oil here.
      Kind regards
      Team @

  13. Asmaa says:

    Hello. I am a 30 year old female. I have hypothyroid and adrenal fatigue. I was also diagnosed with lipedema, which is giving me a lot of pain. I am obese and trying to lose the weight. As of now, I am following a grain free diet (lots of dark leafy vegetables, limited dairy and caffeine, fruits, and protein). I am not losing weight at all and I am exercising. I take one tablespoon of black seed oil in the morning and I have the seeds; I put them on my vegetables and salads. Should I apply the oil to my legs? Please help.

    • nabiblackseed says:

      Dear Asmaa
      Black seed oil does have analgesic properties and you can even feel this in the mouth when taken. Applying it to your legs may help. You should be taking it more regularly and 30 minutes before a meal. Regards the weight loss black seed can increase weight loss in combination with a low calorie and increased exercise lifestyle. Continue with you regime and be patient. Drink water before a meal and simply dont have any high calorie snacks in your home, instead snack on raw fruit and veg (carrot sticks, celery, cucumber, apples) with low fat yoghurt dips.
      We wish you all the best
      Team @ NabiBlackseedOil

  14. GloriaGodoy says:

    Hello, my name is Gloria, I just discovered black seeds and purchased a one pound bag before I read in your website about the oil.
    What is the best way I can use these seeds? I read they can be taken as a tea and I as a condiment in foods. What is the most effective way and how much should be used each time, a teaspoon or two?
    I am 57 years old, 5 feet tall and weigh 107. I suffer from tendon inflammation (aka carpal tunnel) and have osteoarthritis.

    • nabiblackseed says:

      Dear Gloria
      The seeds are great for flavouring foods. They can be used on salad, bread and in curries. They are excellent on pizza or sprinkled on anything with cheese on. If Nigella sativa is being used for health improvement or to treat conditions in general the oil is needed as it delivers a much higher concentration of the valuable healing components than seeds.
      Black seed oil and its components has powerful anti-inflammatory actions. Try one 5ml spoon 30 minutes before each meal (3 or 4 times a day) to start with and see how you go.

      Kind regards
      Team @ NabiBlackseedOil

    • Dan tanner says:

      I recently got some relief after 2 years. The black seed oil alone helped but when I combind it with hemp seed oil the results were amazing and fast. It’s been two weeks now with no pain and I haven’t gone that long in over a year. The docs couldn’t do in 2 years what the oils did in a week. This combination of black seed and hemp seed oils for whatever reason has my body feeling normal again.

    • nabiblackseed says:

      Dear Ray
      It must be taken orally as soon as the Bells palsy starts and continued until resolution. Most Bells palsy will resolve on its own however black seed oil may help this to occur sooner and with less / no residual weakness.
      Take 3 x 5ml spoons daily before a meal with honey.
      Kind regards
      Team @ Nabi Blackseed

    • nabiblackseed says:

      Dear Ayesha
      There are some laboratory studies which have found black seed oil and its active extract thymoquinone have beneficial effects on damaged nerves and also on protecting nerves. No study has looked at facial nerve palsy im humans. Dose is not known but try 5ml 2-3 times daily. If you do take it please update us on how you get along.
      Kind regards
      Team @ NABI blackseed

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