Black Seed Oil for Rheumatoid Arthritis

Black seed oil and its components are showing promise as therapy for a range of autoimmune diseases including rheumatoid arthritis.

Rheumatoid arthritis is an auto-immune disease in which the bodies immune system mounts a response against its own connective tissues. The abnormal immune response results in inflammation of the tissues. If untreated inflammation in rheumatoid arthritis recurs and causes tissue damage.

The connective tissue affected in rheumatoid arthritis is commonly in the joints however it  can affect other parts of the body including the lungs, skin, heart. Traditionally rheumatoid arthritis was treated with steroids to dampen the inflammation and suppress the abnormal immune response.

Long term control of the disease often requires use of dugs which modify the immune system (immunomodulator therapy). Although these drugs help to preserve function and reduce flare-ups of the condition they come with a large number of potential side effects including liver damage.

Black seed oil possesses many properties which make is a potential natural therapy for patients with rheumatoid arthritis: –

  • Analgesic (pain relieving)
  • Anti-inflammatory
  • Immunomodulator (regulates immune system)
  • Hepato / reno – protective (protects liver / kidneys)
rheumatoid-arthritis-black-seed-oil
black seed oil, just 1 capsule taken twice a day was effective in reducing inflammatory markers, DAS-28 score (a measure of disease activity in rheumatoid arthritis) and an improved number of swollen joints compared with baseline and placebo groups

Studies examining the effects of black seed oil on rheumatoid arthritis…

A lab based study examined the effects of thymoquinone (volatile oil of black seed oil)  in an animal model of rheumatoid arthritis. [1]

The results of this study confirmed that clinical and radiological signs of rheumatoid arthritis were suppressed in arthritis in rats who took the extract of black seed oil.

A randomised placebo controlled study on patients suffering from rheumatoid arthritis [2]

The beneficial effects of black seed oil on all the symptoms of rheumatoid arthritis was confirmed. The study found that the rheumatoid arthritis disease activity score improved in group of patients taking black seed oil. The number of swollen joints and the duration of morning stiffness all improved significantly more in the group taking  Nigella sativa oil compared to placebo.

A study which aimed to examine the molecular mechanisms which make black seed oil extract thymoquinone protective against rheumatoid arthritis [3]

The study examined isolated human rheumatoid arthritis fibroblast-like synoviocytes (joint lining cells) and a rat adjuvant-induced arthritis model of rheumatoid arthritis.

The main aim of the study was to investigate the influence of thymoquinone on the major signalling pathways involved in disease  changes in rheumatoid arthritis. The study concluded that thymoquinone abolishes a number of factors known to be involved in rheumatoid arthritis and that it is a clinically valuable agent in the prevention of joint diseases.

Additionally, black seed oil is proven in many studies to protect the liver and the kidneys  from damage, this effect could prove protective for those taking conventional drugs for rheumatoid arthritis.


1. Tekeoglu I, Dogan A, Ediz L, et al.  Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models. Phytother Res. 2007 Sep;21(9):895-7.
2. Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 2012 Aug;26(8):1246-8.
3. Vaillancourt F, Silva P, Shi Q, et al. Elucidation of molecular mechanisms underlying the protective effects of thymoquinone against rheumatoid arthritis. J Cell Biochem. 2011 Jan;112(1):107-17. doi: 10.1002/jcb.22884.
Summary
Black Seed Oil for Rheumatoid Arthritis
Article Name
Black Seed Oil for Rheumatoid Arthritis
Description
Black seed oil and its components are showing promise as therapy for a range of autoimmune diseases including rheumatoid arthritis.
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19 thoughts on “Black Seed Oil for Rheumatoid Arthritis

    • nabiblackseed says:

      Dear Darleen
      Sjogrens is an autoimmune disease in which glands in the body are inflamed. Black seed oil is an immune system modulator and also anti inflammatory. It has been proven to be beneficial in other autoimmune disorders and I think it would be beneficial to try it in yours.
      What problems with prostate does your father have?
      Kind regards
      Team @ NabiBlackSeedOil.com

  1. Connie says:

    17 yr old daughter with rheumatoid arthritis- lot of swelling in knee, painful when she does a lot of walking or exercise. What dosage would you recommend?
    I have asthma, was told to take 1 tsp of black seed oil daily, not the capsules. Is this the dose you would recommend?

    • nabiblackseed says:

      Dear Jamal
      No specific study has looked at the effects of black seed oil on nephrotic syndrome. Multiple studies have found both black seed oil and its active component thymoquinone to protect the kidneys in rats from many different damaging insults and one study did conclude “thymoquinone might be applicable as a protective agent for proteinuria and hyperlipidemia associated with nephrotic syndrome” See here.
      Kind regards
      Team @ NabiBlackSeedOil.com

  2. Jarina patel says:

    Jarina

    I have reumatoid arthritis in most joints I can only take the capsules, how many capsules should I take daily.
    Thank you

    • nabiblackseed says:

      Dear Jarina
      A recent study looking at the benefits of black seed oil on the immune system in 43 patients with rheumatoid arthritis for 2 months has found that just 1 capsule taken twice a day was effective in reducing inflammatory markers, DAS-28 score (a measure of disease activity in rheumatoid arthritis) and an improved number of swollen joints compared with baseline and placebo groups.
      The answer is not that straight forward unfortunately and will depend on why you are taking it. It should help with inflammatory symptoms such as pain and swelling at that dose but if you are using it to protect your organs or for severe active disease you will likely need higher doses and the best way to take this is with oil.
      If you cannot take black seed oil due to taste there are a number of things you can do to help the most important one is to keep the oil in the fridge and take it cold with some honey. It is very pleasant this way.
      Kind regards
      Team @ Nabi Blackseed

  3. Biswas Mishra says:

    i am 16 years old and suffering from rheumatoid arthritis how much black seed should i take daily to cure my inflammations

    • nabiblackseed says:

      Dear Biswas
      Take one 5ml spoon three times a day for 2 weeks then you can reduce it to twice a day for 2 weeks and then continue with 1 spoon daily as maintenance.
      Kind regards
      Team @ Nabi Blackseed

    • nabiblackseed says:

      Dear Biswas
      Please start with three 5ml spoons a day for active inflammation. It may need to be higher depending on your height / weight. For maintenance in rheumatoid arthritis one or two spoons per day is enough.
      Kind regards
      Team @ Nabi Blackseed

  4. Shaheena Shaik says:

    Hi,
    My mother is suffering from rheumatoid arthritis.
    Cant we use black cumin seeds ?
    I asked her to use crushed black cumin seeds with honey and apple cider vinegar!
    Is this a good combination?
    Should the seeds be substituted with oil?
    Or both has the same effect in the case of arthritis. Please suggest..

  5. Optimistic says:

    Hi,

    I have a friend who has Rheumatoid arthritis. She’s currently on methotrexate and prednisone. I think it would be beneficial for her to start a black seed oil regimen. However… she would have to be weaned off the methotrexate and predinsone because of the dosage and length of time she’s been on these medications. I understand she would have to consult her physician first but do you know of any studies that have examined the usage of black seed oil in patients taking these two medications or any information on possible drug interactions? Is it safe to take black seed oil while on immunosuppressant medications?

    Thank you,
    Optimistic for my friend

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